Pathogenic T and B Cells of Lupus Reveal a Major Autoepitope That Primes Naturally Processed Chromatin Peptides
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منابع مشابه
Naturally processed chromatin peptides reveal a major autoepitope that primes pathogenic T and B cells of lupus.
Major autoepitopes for pathogenic Th cells of lupus were previously found in core histones of nucleosomes by testing overlapping synthetic peptides. To detect other dominant epitopes, we eluted peptides from MHC class II molecules of a murine lupus APC line that was fed with crude chromatin. The eluted peptides were purified by reverse-phase HPLC and tested for their ability to stimulate autoim...
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تاریخ انتشار 2002